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Here we demonstrate in a range of CRC models that 5FU treatment promotes mitochondrial biogenesis and increases mitochondrial function in surviving cells

Independent replications largely failed

Source Data Figure 3 (download PPTX Raw immunofluorescence tissue section images and raw hematoxylin and eosin stained tissue section images (raw, uncropped versions embedded in file)

A preliminary study in LLD showed numerical, non-significant increases in SV2A with post-electroconvulsive therapy (ECT) compared to pre-treatment [257]

Reduction in major cardiovascular events (SELECT trial, semaglutide) Reduced risk of progressing from prediabetes to type 2 diabetes (Tirzepatide, 3yr trial) Weight reduction significantly improves sleep apnea severity confirmed in multiple GLP-1 trials Emerging ADA 2026 data on GLP-1 anti-inflammatory effects and osteoarthritis improvement Improved basal metabolic rate and energy utilisation, especially with tirzepatides GIP pathway We believe cost transparency is part of quality care