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Pregnancy and lactation represent relative contraindications given absence of human safety data in these populations despite reassuring preclinical reproductive toxicology studies

reported that changes in the NP affected ion regulation within this disc region, which led to dysregulated cellular homeostasis and fibrotic changes to the tissue (Zhang et al., 2018)

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In addition, deletions in the 15q13.3 region that contains the CHRNA7 gene, which encodes the 7nAChR, are linked to a range of neurodevelopmental problems, including ASD [162, 163]

They found that riluzole increased the proportion of GABA relative to the other chemicals in adults with autism and lowered it, albeit only slightly, in controls