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The primary concern with hepatic impairment is a potential change in exposure to a drug that is extensively cleared by hepatic metabolism or biliary excretion via the liver, that could impact on the pharmacodynamic action or lead to adverse effects [19]

The latter develops when the level of LPS in the blood increases and this leads to the activation of a pro-inflammatory immune response triggering systemic low-grade inflammation (Mohammad and Thiemermann, 2021)

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Mice were euthanized when the tumor reached 2 cm in size [128]