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Due to the lack of adequate antioxidant systems, the brain and nervous system are easily affected by oxidative stress (114)

More hydrophilic conjugates would be expected to display a decreased binding to plasma proteins, but published investigations suggested that a change in plasma protein binding was dependent on the polyphenol and its type and position of conjugation ( TABLE 3 Degree of phase II conjugation of compounds detected in serum/plasma after intake of Pycnogenol and plasma protein binding of Pycnogenol constituents and metabolites

7 (2), e1001271

Exosomes derived from human umbilical cord mesenchymal stem cells decrease neuroinflammation and facilitate the restoration of nerve function in rats suffering from intracerebral hemorrhage