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These results emphasize the dual roles of p53 in ferroptosis

Several sets of dissociation constants (pKa values) have been reported (Table 1), although it is not always clear at what conditions these values were determined, since proper referencing is sometimes missing

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While these findings provide critical new light on molecular determinants of eukaryotic Atm1 proteins, additional structural and functional characterization is essential to fully decipher the Atm1 transport mechanism

Therefore, the ferroptosis-promoting effect of targeting p53 in lung cancer should be well utilized