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Sleep improvements appear within the first one to two weeks

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Funding This work was supported by the National Natural Science Foundation of China (grant numbers 82173424, 81974476, 81673065, 81830096, 81773341) and the Program of Introducing Talents of Discipline to Universities (111 Project, grant number B20017)

Dissolution testing was done in FEDGAS (Fed State Simulated Gastric Fluid) at pH 6

A combination of keywords related to alpha-synuclein, synaptic plasticity and Parkinsons disease was used: alpha-synuclein, neuroinflammation, neurodegeneration, Lewy bodies, Parkinsons disease, striatal dopaminergic transmission, synucleinopathies, synaptopathy, synaptic plasticity, presynaptic, postsynaptic, toxicity, misfolded, aggregation, oligomers, fibrils, animal models, mechanisms, Lewy body dementia, multiple system atrophy, pure autonomic failure, REM behavior disorder