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10.1093/advances/nmac032 87

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Aquilano K., Baldelli S., Ciriolo M.R

PT2385 is one of the very few HIF-2 inhibitors investigated in preclinical models of GBM and works by preventing allosteric heterodimerization with HIF-1 when it binds to HIF-2 PAS-B domain (156)

Indeed, it is already known that obesity induces chronic inflammation, which has negative effects on stem cells with acquired DNA damage, including those in the context of germline loss of MMR function, such as in LS [48]