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In comparison, in the high-overdose patient (D), the maximum number of necrosed cells was 1,754 out of 5,114 cells (34.29%) without zonation, which increased to 2,012 upon applying 80% zonation (see Figure 4)

Abnormally elevated GGT or ALP levels at baseline were observed in 209 (23%) and 172 (19%) patients, respectively, and concomitant elevations of GGT and ALP in 68 (7%)

Contradictorily, high levels of serum HGF and overactive HGF/c-MET pathway in DLBCL patients have been also reported to be linked with unfavorable outcome in several studies [26, 27]