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Pyruvate is metabolized to lactate in the cytosol or converted to acetyl coenzyme A (acetyl-CoA) in the mitochondria to fuel the tricarboxylic acid (TCA) cycle, enhance OXPHOS, and generate ATP [18,19]

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While good responders ( n = 4) achieved complete remission (CR) or a complete remission with incomplete hematologic recovery (CRI), poor responders ( n = 10) only reached cytoreduction or stable disease after Venetoclax treatment (Supplementary Table 1)

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But it is possible generally under extreme conditions when you are drinking more than 12 liters in 24 hours or exercising heavily to disrupt the bodys osmotic balance by diluting and flushing too much sodium, an electrolyte that helps balance the pressure of fluids inside and outside of cells