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The simplest way to picture it: GLP-1 tells your gut to slow down, while amylin tells your brain you are full - through a different channel

Administer by subcutaneous injection (under the skin)

Research in humans is a bit less impressive Clinical trials in humans A 1981 double-blind study found that chronic insomniac patients found that subjects slept 59% more, shorter sleep latency, and higher sleep efficiency (Schneider 1981) A 1987 double-blind study did not find any statistically significant changes in sleep structure as measured by REM sleep, NREM sleep, or total sleep time (Debellis 1987) A 1992 double-blind study in 14 chronic insomnia patients found higher sleep efficiency and subjectively estimated tiredness decreased to similar levels of healthy subjects in 7 nights of injections (Schneider 1992) There are some limitations to these studies however

Insulin from food can blunt the GH response

Continuous use without breaks can reduce receptor sensitivity and potentially cause copper dysregulation