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Major classes of RLS include lipid aldehydes, ,-unsaturated carbonyls, and nitroalkenes (discussed in Esterbauer et al., 1991

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Associations of baseline levels of TMAO, choline and L- carnitine with cognitive function over time was estimated using a linear mixed model adjusted for demographics, vascular risk factors (hypertension, atrial fibrillation, diabetes mellitus, dyslipidemia, history of coronary artery disease), life style factors (smoking, body mass index), stroke severity, and ischemic stroke subtype

These effects were generally mild to moderate in intensity and were most frequent during the dose escalation period, becoming less common as participants remained on their maintenance dose

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