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However, treatments with GABA, DSIP-CBBBP, and DSIP all resulted in increased struggle times compared to the model group, with CBBBP alone not showing a similar effect, indicating a differential impact on depressive-like behaviors and highlighting the potential therapeutic value of these treatments in addressing depressive symptoms associated with insomnia (Riemann et al., 2020

Additionally, alcohol can exacerbate gastrointestinal side effects such as nausea and may contribute to dehydration if combined with vomiting or diarrhea caused by the medication