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Phosphorylation sites with missing values in more than 50% of samples were filtered out and the following key parameters were used: weight = 0, statistic = area.under.RES, output.score.type = NES, nperm = 1000 and min.overlap = 5

Saliva was collected in ice-cooled plastic tubes for 10 min after the appearance of the first drop and subsequently stored at 80 C for up to 20 days before analysis (Narita et al