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Description

It has been shown that secretion of INF- activates immune cells (e.g., CD8 + T cells), which downregulates the expression of xc system components to suppress cellular uptake of cystine, promoting ferroptosis induced by glutathione depletion (Zhong et al., 2022)

(PubMed) Chen W, Qi J, Feng F, et al

Drugs 32 , 9971001 (2023)

Y., Rehal, S

At the level of thyroid hormone synthesis, TNF- can directly inhibit the activity of thyroid peroxidase (TPO), and IL-1 stimulates iodothyronine 5-deiodine activity in the liver to affect the metabolism of thyroid hormone (Fujii et al., 1989)