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H 2 O 2 , an endogenous oxidant produced by activated macrophages and many pathophysiological stimuli, has been widely used to induce oxidative stress in different cell lines 3,59

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Characterization of the oxidase activity in mammalian catalase

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This hypothesis is further supported by transcriptomic-metabolomic evidence linking sphingolipid metabolism to regulating subcutaneous adiposity in beef cattle 56 considering that this pathway may induce insulin resistance 57