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Description

However, in sepsis-associated acute lung injury (SI-ALI), neutrophil extracellular traps (NETs) activate the TLR9/MyD88/NF-B pathway to upregulate METTL3 expression, which induces the m 6 A methylation of GPX4 mRNAs, inhibiting GPX4 expression and increasing the ferroptosis of alveolar epithelial cells[169]