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This theory is often referred to as the methyl trap hypothesis. In simple terms, folate may help improve certain blood markers associated with anemia even when vitamin B12 levels remain low

Classically, the posterior columns and corticospinal tracts of the spinal cord are affected, and hence the name combined systems degeneration

This is the reason why the fundamental criteria for injectable B12the route of administration and the severity of the underlying conditionhave not changed

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Alcohol also decreases the flow of oxygen to the skin, as does smoking