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She will also have the Methyl when it arrives

NNMT is an enzyme that catalyzes the methylation of nicotinamide (a NAD+ precursor) and other substrates, using SAM (S-adenosylmethionine) as the methyl donor

(8) Creatinine and the estimated glomerular filtration rate (eGFR) provide the baseline for judging whether kidney disease is contributing to the elevated B12

A practical heuristic: if youre set on using a modified form, the more conservative middle-ground protocols (1 mg/day for 20 days for N-acetyl amidate, or 1-2 mg for amidate alone) sit closer to the dose math that would be theoretically equivalent to the base epithalon protocols if the modifications deliver something like 5-10x bioavailability improvement

This material is based upon work supported by the U.S