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piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair

HIF-1 up-regulates the expression of Glutaminase (GLS) to promote the decomposition of glutamine into glutamate, which is further converted to -ketoglutarate (-KG), which enters the tricarboxylic acid cycle (TCA cycle) to support energy production (67)