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89 , 2025S2039S (2009)

Paraquat has been shown to accumulate in neuromelanin and demonstrate an affinity for it [79, 80]

FIGURE 1 4.1 Glycolysis, oxidative phosphorylation, and the pentose-phosphate pathway In general, pro-inflammatory activation of macrophages for example by pathogen associated molecular patterns (PAMPs) as Toll-like receptor (TLR) stimulation - induces a profound metabolic reorganization that is characterized by an increase in glucose uptake and glycolysis, a disrupted TCA cycle and (depending on the stimulus) a reduction in OXPHOS (Rodrguez-Prados et al., 2010

doi: 10.3390/ijms232315445 140 SahooDK

As detailed in Section 2.1, DJ-1 maintains the activity of SAHH, ensuring the production of homocysteine and subsequently cysteine for GSH synthesis