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Mechanistically, lactate accumulation, driven by PKM2, enhances Twist1-K150la, which in turn facilitates Twist1 phosphorylation, nuclear translocation, and regulation of TGFB1 transcription, thereby inducing an EndoMT-associated fibrotic phenotype in ischemic flaps

( e ) The relative FLVCR1b mRNA level and the heme concentration in MCF-7 cells during ROS oscillation were measured

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

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