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2011 Jul;94(1):359S-365S

A number of studies have implicated genes such as MTHFR (Methyltetrahydrofolate Reductase) in migraine headaches

The study further elucidated the signaling pathway involved, showing that BPC 157 enhanced the phosphorylation of Src, Caveolin-1 (Cav-1), and endothelial nitric oxide synthase (eNOS)