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Through its activation, seladelpar triggers the induction of fibroblast growth factor 21 (FGF21) from hepatocytes, activates c-Jun N-terminal kinase (JNK) signaling pathway, and subsequently inhibits cholesterol 7-hydroxylase (CYP7A1), the rate-limiting enzyme for bile acid synthesis and accumulation

Some formulas, especially those with B-complex and vitamin C, cause a faint metallic or vitamin taste in the mouth