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However, for patients with advanced fibrosis, especially those that progress to cirrhosis or are accompanied with some uncontrollable clinical symptoms, liver transplantation is ultimately the only option (10)

Low glutathione levels are associated with chronic inflammation, mitochondrial superoxide production and oxidative protein / DNA damage

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Upregulation of AKT promoted the expression of Pirin and subsequent activation of nuclear factor erythroid 2related factor 2 (Nrf2) and the NF-B signaling cascade, protecting cells from OS effects on viability [53]

10.1007/BF00873919 Invest New Drugs 141 MurataJ