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Characteristic clinical manifestations included early infantile onset hypotonia, swallowing, speech difficulties, respiratory insufficiencies, and a fatal course (seven died within the first year of life and one at age 16 years)

As with fetal glucocorticoids, postnatal glucocorticoids or stress can alter synaptic pruning and can also lead to reduced GR expression in brain regions important for glucocorticoid negative feedback, the hypothalamus and hippocampus ( These effects of the perinatal environment on GR can be imposed long-term via changes to the epigenome

Sacks and Noben-Trauth, 2002

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The standard deviation tells you how tightly your data is clustered around the mean