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Disc chondrocyte transplantation in a canine model: a treatment for degenerated or damaged intervertebral disc

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Other autophagy enhancers, such as spermidine, also indirectly diminish mtDNA release by promoting the clearance of defective mitochondria [195]

Chronic pain involves persistent nociceptor and microglial overactivation, which leads to electron transport chain (ETC) dysfunction in neuronal mitochondria and excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)