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However it should be noted that the biological activities and therapeutic effects of polyphenols are also potentially mediated by their metabolites formed in the gut, liver, or gut microbiota, therefore demonstrating the complexity of polyphenols in this context [589,590]

While translational gaps persist, particularly in dosing, timing, and patient stratification, emerging strategies including mitochondria-targeted antioxidants, nanotherapeutics, and biomarker-guided interventions hold promise for restoring redox homeostasis and improving clinical outcomes

& Anh, H

Shi X, Zhang Y, Wang L,Xiong M

Zhuang Y, Liu K, He Q, Gu X, Jiang C, Wu J