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Iron deposition leads to hyperphosphorylation of tau and disruption of insulin signaling

Furthermore, some trials lack blinding or placebo control, increasing the risk of bias

doi: 10.1038/s41598-019-44816-w 157 SatoD.LionelA

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In this context, CYP2D6 substrates such as paroxetine, fluoxetine, venlafaxine, and adjunctive aripiprazole are at increased risk of rapid clearance and underexposure, predisposing to non-response despite adequate dosing (Nahid and Johnson, 2022)