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Vandin F, Papoutsaki A, Raphael BJ, et al

In the lab, scientists can create methylcobalamin by using sodium borohydride to reduce cyanocobalamin in an alkaline solution and then adding methyl iodide

Elife (2022) 11:e74549

78 Importantly, our evidence indicated the safety of selenium supplementation at doses ranging from 80 to 400 g per day for up to 12 months by showing comparable adverse events between the selenium-treated and control groups, filling a notable gap where such safety analyses were lacking