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However, with persistent stress, the HPA axis becomes hyperactivated, leading to excessive glucocorticoid release and dysregulation of its negative feedback loop (Iob et al., 2020

2019;33 doi: 10.1002/jbt.22256

Future research should further validate the specificity and sensitivity of TfR1 as an early diagnostic marker and develop cost-effective detection technologies

Compliance and side effects were determined from an interview

Dual-luciferase reporter assay Luciferase reporter assays were performed using the Secrete-Pair TM Dual Luminescence Assay Kit (GeneCopoeia, USA) according to the manufacturers instructions