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Substances decreasing the plasma concentrations of COCs and potentially diminishing the efficacy of COCs: Drugs or herbal products that induce certain enzymes, including cytochrome P450 3A4 (CYP3A4), may decrease the plasma concentrations of COCs and potentially diminish the effectiveness of COCs or increase breakthrough bleeding

Another group also received the devices and 7.2 mg nicotine cartridges, but later in the study they were switched to 5.4 mg nicotine cartridges

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It has great sway over the government, which still owns 33% of the business