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Journal of Neuroscience Research, 2012

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This critical window of GM development aligns with critical windows of development of other systems that are also more sensitive and vulnerable to environmental input, such as the immune system, HPA axis, and brain development in general

(It is best to learn this maneuver at a time when you don't have the cramp.) Another technique involves flexing the ankle by pulling the toes up toward the head while still lying in bed with the leg as straight as possible