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This flexibility of the cap domain is consistent with the observation that helices D1, D2, and D3 in D14 underwent a large structural change upon binding to MAX2 17

Although few studies have directly examined autophagy in the context of testicular regeneration, available evidence suggests that transient induction is protective, whereas chronic overactivation is detrimental

Similarly, it has also been shown that GPX4 is degraded by interacting with different autophagic receptors after Fin56 (type 3 ferroptosis inducer) or excessive copper treatment, triggering ferroptosis [205, 206]

A Dual ELP-Tagged Split Intein System for Non-Chromatographic Recombinant Protein Purification

It was additionally identified as a host cell factor of HCV 46 and demonstrated to be a relevant host factor for SARS-CoV-2 infections in two CRISPR-Cas9 knockout screens 33,34