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First, autophagy plays a protective role by inhibiting oxidative damage and apoptosis in CuSO 4 -induced testicular injury and spermatogenesis disruption, and second, autophagy plays an adverse role by promoting ferroptosis, thus aggravating the toxicity caused by CuSO 4 [100]

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Although research on the mechanism of opioid tolerance is still in full swing, there is no doubt that the imbalance of the desensitizationinternalizationresensitization of MOR plays a crucial role [15], which is also the main focus of our review

Each formulation is produced under stringent quality controls and rigorously tested for purity and consistency, ensuring reliable and precise dosing for controlled research applications