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Studies of chondrocyte cultures suggest that it promotes proteoglycan and type II collagen synthesis, which has driven exploration of potential utility in joint and cartilage repair models

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GBM is characterized by anaplasia, nuclear atypia, cellular pleomorphism, mitotic activity, and, most remarkably, alternated phases of rapid proliferation and aggressive invasion of the surrounding brain tissue, which inevitably leads to critical recurrence after surgical resection of the main tumor mass [3, 4]

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