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Watch for behavioral changes including increased usage patterns and neglect of daily responsibilities

The one everyone quotes is molecular weight: Under ~500 Da is the rough cutoff for good passive oral absorption

And, you know, and then you understand the methodology behind why these things are important and you understand, okay, yes, there is a genetic component, so I what part of me could be benefited from some of the same therapeutics or dietary, you know, interventions and we just learn as we go

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In the context of SSRIs one can see that as the concentration of the ligand changes, binding to variable numbers of receptors changes