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Its three, all at once. Three hormones that control your sleep A 2025 review in the Journal of Clinical Medicine traced perimenopausal sleep disruption to an overlap: declining estrogen and progesterone alongside age-related shifts in stress hormones and circadian rhythm

doi: 10.3389/fgene.2021.654804, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 53.Fu L, Wang Y, Li T, Yang S, Hu YQ

In the past 8 years, four meta-analyses, including 1626 RCTs each, have pooled the data from studies comparing prostaglandin E1 (PE1) with and without B12 and with or without additional alpha-lipoic acid

53 Although dementia was not a primary outcome, a pooled analysis of 15,820 patients with type 2 diabetes randomised to GLP-1 receptor agonist treatment or placebo found a 50% reduction in dementia progression over a median of 3.6 years (15 cases in the placebo group vs 32 in the GLP-1 receptor agonist group)

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