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Expression of the Apx gene family during leaf senescence of Arabidopsis thaliana

Though subsequent events after protein binding were cause for controversy initially (detailed in the section on ferroptosis), progress in resolving this issue was made when it was shown that an oxidant stress was not observed during metabolism of APAP [23, 24] but only after the drug metabolism phase was completed, and that the oxidant stress was located within mitochondria [25, 26]

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Biological activities of reactive oxygen and nitrogen species: Oxidative stress versus signal transduction