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Involvement of reactive oxygen species in meiotic cell cycle regulation and apoptosis in mammalian oocytes

The first binding site is located at the entrance of the substrate-binding pocket and blocks substrate entry to the active site

Because of its known role in renal detoxification and its low toxicity, GSH has been explored as an adjunct therapy for patients undergoing cancer chemotherapy with nephrotoxic agents such as cisplatin, in order to reduce systemic toxicity