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The enzyme DHODH acts as a safeguard against ferroptosis in eye tissues like the cornea and retina without relying on GPX4, but when this protective pathway is diminished, particularly when disrupted by oxidative stress, it could lead to damage of corneal and retinal cells by facilitating the progress of ferroptosis

Peptides can contribute substrates, but they do not replace adequate calories, essential amino acids, fatty acids, vitamins, and minerals

To address these challenges, future research should prioritize combination treatment approaches that simultaneously target multiple amino acid transporters or metabolic pathways

Circular beta-lactamase: stability enhancement by cyclizing the backbone

PBPK models for the prediction of in vivo performance of oral dosage forms