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You are asking your body to make something that partially burns fat versus giving it a compound that was engineered specifically to burn fat at record levels

The Myth of "More is Better" A common misconception in the supplement world is that a higher milligram count always equals a better result

its Fe-S occupancy is rate-limiting for overall lipoylation and is gated by FDX1, a ferredoxin that donates electronsand, indirectly, Fe-S-derived ironto the lipoate synthase reaction

This is a completely different regulatory pathway

doi: 10.1038/nrrheum.2014.137 85 ChoudhuryMYinXSchaefbauerKJKangJHRoyBKottomTJet al