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Data analysis The Statistical Package for the Social Sciences (version 22.0 for Windows, SPSS Inc., Chicago, IL, USA) was used for statistical analysis

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Apart from ER stress, liver-specific overexpression of NACHT, Leucine-rich-repeat and pyrin domain-containing protein 3 (NLRP3) induced marked HSC activation and fibrosis, indicating a possible role of inflammatory cell death in inducing HSC activation (Wree et al., 2014)

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Formulation The combination of excipients with the active pharmaceutical ingredient