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Vitamin B12 injections are the most common way to prevent or treat a deficiency

For example, polysaccharides extracted from Polygonum multiflorum increase populations of Bifidobacterium and Lactobacillus while decreasing Helicobacter , thereby alleviating gut dysbiosis and contributing to IBD management (119)

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Oxidative stress is exacerbated by methotrexate, which induces lipid peroxidation and depletes antioxidants like glutathione (GSH)

Among them, protein kinase C (PKC), a family of protein kinase enzymes involved in various cellular mechanisms, has been shown to phosphorylate NRF2 at Ser40 in its Neh2 domain, disrupting the association with KEAP1 and promoting its activation [203, 204]