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Unrestricted activation of endosomal TLRs (eTLRs) triggers inflammatory pathways, leading to a broad range of diseases and pathological processes, including rheumatoid arthritis (RA) 6,8 , systemic lupus erythematosus (SLE) 6,8,9 , juvenile idiopathic arthritis (JIA) 10,11 , autoimmune type 1 diabetes 12 and ischemiareperfusion injury 13

Compared to natural enzymes, they are much more advantageous and have unique biological and physical characteristics [19, 28]

One well-characterized non-histone substrate is HMGB1, a chromatin-binding protein with extracellular cytokine-like activity

Pancoast, Quaker Forty-Niner, 233

Moreover, some of these traditional practices may be harmful for the eyes as well