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Cell (2015) 160(1-2):6273

Mandal M, Rajput M, Anura A, et al

Additional research, including studies from our collaborative research groups, has shown that severe reactive astrocytes exhibit the increased production of H 2 O 2 through MAO-B, leading to AD pathology hallmarks such as tauopathy, cognitive decline and neuronal atrophy 57

phyto-exosomes deliver barrier-replenishing proteins and lipids, while acetyl zingerone, an antioxidant, enhances the effects of vitamin C

Notably, reactive astrocytes closely interact with A plaques and degrade A plaques in an apolipoprotein E epsilon 4 (APOE) gene-dependent manner by releasing amyloid-degrading enzymes such as insulin-degrading enzyme (IDE) and matrix metalloproteinases (MMP-2, MMP-9) 48,49