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Additionally, ERK5 silencing induced phosphorylation and activation of JNK, resulting in phosphorylation of IRS-1 on inhibitory residues (S307)

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Remarkably, when the OSBPL2 gene is knocked out in mice, hearing loss does not occur, while a loss of hearing occurs when the mutated OSBPL2 protein is expressed following autosomal dominant mutations

Most post-travel infections become apparent soon after returning from abroad, but incubation periods vary, and some syndromes can present months to years after the initial infection or after travel (Fairley, 2023)