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Large phase III trials demonstrated that hippocampal-avoidance whole brain radiotherapy (HA-WBRT) plus memantine significantly preserved cognitive function compared to conventional WBRT, establishing this approach as a new standard in managing RIBI

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separation was achieved by 5% B for 2 column volumes (CV), which was increased linearly to 50% B over 15 CV, then to 100% B over 3 CV and held at 100% B for 5 CV, before returning to 80% B for 3 CV

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This clustering activity of -synuclein restricts synaptic vesicle motility [146], and thereby likely affects the kinetics of neurotransmitter release