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These effects were observed also in PCOS mice receiving the second formulation containing 0.40 mg LC, 0.20 mg ALC, and 0.08 mg PLC (mouse/day), where a decrease in serum levels of testosterone was also reported

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Combined interventions targeting MPC dysfunction, ROS buffering systems such as the Nrf2GSH axis, or mitophagy pathways including PINK1, may disrupt the self-sustaining signalmetabolism circuit and offer a strategy to delay or reverse acquired therapeutic resistance