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Physiological application of methionine supplementation is dose-dependent, for instance, a low methionine diet suppresses the neurogenesis in animal models, whereas high dietary methionine has been associated with mild cognitive impairment primarily due to mitochondrial dysfunction (197)

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Coronary heart disease (CHD) is a globally prevalent cardiovascular disorder with a complex pathogenesis associated with multiple risk factors, including high-level low-density lipoprotein cholesterol, smoking, chronic kidney disease, diabetes and hypertension (1)

10.1126/science.aaw9872 7 BaoW.-D.PangP.ZhouX.-T.HuF.XiongW.ChenK.et al (2021)

Pomiferin, especially at 300 mg/kg, preserved mitochondrial integrity and exerted anti-apoptotic effects