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Ethics statement The studies involving humans were approved by Amsterdam UMC location, Vrije Universiteit Amsterdam, Department of Hematology/Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam, The Netherlands

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In individuals with knee osteoarthritis, the level of hyaluronic acid decreases, leading to increased friction, pain, and stiffness

Folate deficiency anemia low folate (B-9), sometimes confused with B-6

Cumulatively, these studies indicate that the therapeutic performance of CQDs in photodynamic and photothermal applications is fundamentally governed by synthesis-driven modulation of photophysical properties rather than by the carbon core alone